Spectroscopic data for a side product in the synthesis is We provide here precise geometrical parameters for the The origina l geometry proposed by Tebbe.9 For the first time,Īnd nearly 40 years after Tebbe’s ground-breaking experiment, In this note, we report highquality X-ray data of 1 (grown as a cocrystal with an impurity)Īnd discuss a high-resolution solid-state structure confirming Readily, under an inert atmosphere, by addition of a slightĮxcess of AlMe3 to Cp2TiCl2 in toluene in yields ranging fromĨ0 to 90% (eq 1).9 In the presence of a suitable Lewis base, 1 Were performed much earlier in the summer of 1974 at theĭuPont Central Research Division.10 Compound 1 is prepared
Grubbs, and Schrock.6−8 Although reagent 1 was first reportedīy Tebbe and co-workers in 1978,9 the original experiments This well-known process ultimatelyĬulminated in the 2005 Nobel Prize being awarded to Chauvin, Methylidene transfer reactions2−5 which proceed through a
Species via metallo-Wittig chemistry was later extended to other Its ability to transfer a methylene group to organic Stands as a historic milestone in the field of organometallicĬhemistry. Representation of a titanium methylidene adduct with diphilic AlClMe2. Mounted and data collected to high resolution, thereby providing for the first time a solid-state SingleĬrystals of 1 and 2, despite being extremely reactive and forming an amorphous white coat, can be Rick Thompson,†,§ Eiko Nakamaru-Ogiso,‡ Chun-Hsing Chen,*,† Maren Pink,*,†ĭepartment of Chemistry and the Molecular Structure Center, Indiana University, Bloomington, Indiana 47405, United Statesĭepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, 295 John Morgan Building,ģ620 Hamilton Walk, Philadelphia, Pennsylvania 19104, United StatesĪBSTRACT: The Tebbe reagent, (1), has finally been structurallyĬharacterized due to the fortuitous formation of cocrystals of 1 and (2). Structural Elucidation of the Illustrious Tebbe Reagent
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